5.12 Corticosteriods
Corticosteroids can be prescribed in a variety of routes. Fluticasone is an example of a commonly used inhaled corticosteroid that can be inhaled or used as a nasal spray. Prednisone is an example of a commonly used oral corticosteroid, and methylprednisolone is a commonly used IV corticosteroid. Additional information about corticosteroids and potential adrenal effects is located in the “Corticosteroids” section of the “Endocrine System” chapter.
Mechanism of Action: Fluticasone is a locally acting anti-inflammatory and immune modifier. The nasal spray is used for allergies, and the oral inhaler is used for long-term control of asthma. Fluticasone is also used in a combination product with salmeterol. It decreases the frequency and severity of asthma attacks and improves overall asthma symptoms. See Figures 5.15-17[1],[2],[3] for images of different formulations of fluticasone.
Oral prednisone prevents the release of substances in the body that cause inflammation. It also suppresses the immune system.
Methylprednisolone IV prevents the release of substances in the body that cause inflammation. It also suppresses the immune system. Methylprednisolone comes in powder form and must be reconstituted (mixed) with sterile saline before administration. See Figure 5.17[4] for an image of methylprednisolone.
Indications: Fluticasone inhalers are used to prevent asthma attacks. Fluticasone nasal spray is used to reduce inflammation of sinus passages. In respiratory conditions, oral prednisone is used to control severe or incapacitating allergic conditions, severe asthma, and acute exacerbations of COPD. Oral prednisone is also used to relieve contact dermatitis, atopic dermatitis, serum sickness, and drug hypersensitivity reactions. Methylprednisolone IV is used to rapidly control these same conditions.
Nursing Considerations: Fluticasone is safe for children aged 4 years and older. Prednisone and methylprednisolone are safe for all ages.
Side Effects/Adverse Effects: Fluticasone inhalers can cause hoarseness, dry mouth, cough, sore throat, and oropharyngeal candidiasis. Fluticasone nasal spray can cause dry nasal passages and epistaxis (nosebleeds). Clients should rinse their mouths after using corticosteroid inhalers to prevent candidiasis (thrush).
Prednisone and Methylprednisolone: See more information about adverse effects of corticosteroids in the in the “Corticosteroids” section of the “Endocrine System” chapter. Cardiovascular symptoms can include fluid retention, edema, and hypertension. Imbalances such as hypernatremia (↑Na), hypokalemia (↓K+), and increased blood glucose with associated weight gain can occur. CNS symptoms include mood swings and euphoria. GI symptoms can include nausea, vomiting, and GI bleed. In long-term therapy, bone resorption occurs, which increases the risk for fractures; the skin may bruise easily and become paper thin; wound healing is delayed; infections can be masked; and the risk for infection in