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If you are developing Windows CE and mobile apps in C++, as Einar has already mentioned, MFC is a good choice. If you make this choice, MFC then also becomes a reasonable choice for the desktop as you can use the same code across desktop and hand-held devices. MFC remains a good perfomance / easy to implement combinitation in this scenario. Personally, I use MFC in conjunction with Stingray libraries in these enivornments which gives a very good interface, good performance and is quick and easy to implement.