(Other posts on SO are similar, but none have the specific combination of uwsgi + Flask + virtualenv) (This one is closest)

I installed uwsgi via apt-get. I also tried pip install wsgi. Both gave me the same issue.

Test command:

sudo uwsgi -s /tmp/uwsgi.sock -w myapp:app -H myvirtualenv

Result:

Python version: 2.7.4 (default, Apr 19, 2013, 18:35:44)  [GCC 4.7.3]
Set PythonHome to myvirtualenv
ImportError: No module named site

I can otherwise run my app in the virtual env.

python flask virtualenv uwsgi
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