I watched these DNR TV episodes recently and thought they were very well done and informative.
http://www.dnrtv.com/default.aspx?showNum=165
http://www.dnrtv.com/default.aspx?showNum=166
These focus on XNA, which is definitely where I'd start if I was planning on creating a game. Their tutorial take you through:
creating a 2D game with:
If you haven't heard of XNA:
The framework runs on a version of the Common Language Runtime that is optimized for gaming to provide a managed execution environment. The runtime is available for Windows XP, Windows Vista, Windows 7, and Xbox 360 [also can be played on Zune HDs].
XNA attempts to free game developers from writing "repetitive boilerplate code" and to bring different aspects of game production into a single system. wikipedia
Even if you don't want to use XNA, I think these videos will help learn about the concepts and techniques common to most (if not all) game dev. Oh, and it's all C# :)
Good luck!
I would take a look at SDL.Net it's a pretty good games library for .NET (well a binding to a good library for the pedants ;))
It has a lot of resources on its pages right from beginner stuff to more advanced things like isometric engines etc.
It doesn't seem to have been very active for a while however what is there already is more than enough for even complex 2D games.