12
Definitely use "Not", consider reading it aloud.
If you read aloud:
If X is false Then Do Y Do Y
Versus
If Not X Then Do Y
I think you'll find the "Not" route is more natural. Especially if you pick good variable names or functions.
Code Complete has some good rules on variable names. http://cc2e.com/Page.aspx?hid=225 (login is probably required)