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I am making a UI in WPF, I have a bunch of functional areas and I use a Grid to organize it. Now the Grid that I want is not uniform, as in, some functional area will span multiple cells in the Grid. I was wondering what the best practise is in solving this. Should I create one grid and then for each functional area set it to span multiple cells, or should I split it up into multiple nested Grids. In this image, the leftmost panel (panels separated by the gray bar) is what I want. The middle panel shows one grid where the blue lines are overlapped by a functional area. The rightmost panel shows how I could do it with nested grids. You can see the green grid has one horizontal split. In the bottom cell is the yellow Grid with a vertical split. In side the left cell is the red Grid with again a horizontal split. Grids http://www.freeimagehosting.net/uploads/08f2711bae.jpg I was just wondering what is best practise, the middle or the right panel. UPDATE: Just for clarification, a more 'code oriented' example: The Middle panel <Grid> <Grid.RowDefinitions> <RowDefinition Height="25" /> <RowDefinition Height="*" /> <RowDefinition Height="*" /> </Grid.RowDefinitions> <Grid.ColumnDefinitions> <ColumnDefinition Width="200" /> <ColumnDefinition Width="*" /> </Grid.ColumnDefinitions> <Menu Grid.Row="0" Grid.Column="0" Grid.ColumnSpan="2" /> <uc:Info Grid.Row="1" Grid.Column="0" /> <uc:Control Grid.Row="2" Grid.Column="0" /> <uc:Simulation Grid.Row="1" Grid.Column="1" Grid.RowSpan="2" /> </Grid> The Right panel: <Grid> <Grid.RowDefinitions> <RowDefinition Height="25" /> <RowDefinition Height="*" /&g

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