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IIf() runs both the true and false code. For simple things like numeric assignment, this isn't a big deal. But for code that requires any sort of processing, you're wasting cycles running the condition that doesn't match, and possibly causing side effects.
Code illustration:
Module Module1
Sub Main()
Dim test As Boolean = False
Dim result As String = IIf(test, Foo(), Bar())
End Sub
Public Function Foo() As String
Console.WriteLine("Foo!")
Return "Foo"
End Function
Public Function Bar() As String
Console.WriteLine("Bar!")
Return "Bar"
End Function
End Module
Outputs:
Foo!
Bar!