What's the safest way to iterate through the keys of a Perl hash?

If I have a Perl hash with a bunch of (key, value) pairs, what is the preferred method of iterating through all the keys? I have heard that using each may in some way have unintended side effects. So, is that true, and is one of the two following methods best, or is there a better way?

# Method 1
while (my ($key, $value) = each(%hash)) {
    # Something
}

# Method 2
foreach my $key (keys(%hash)) {
    # Something
}