Correct way to detect sequence parameter?

As of 2.6, use abstract base classes.

>>> import collections
>>> isinstance([], collections.Sequence)
True
>>> isinstance(0, collections.Sequence)
False

Furthermore ABC's can be customized to account for exceptions, such as not considering strings to be sequences. Here an example:

import abc
import collections

class Atomic(object):
    __metaclass__ = abc.ABCMeta
    @classmethod
    def __subclasshook__(cls, other):
        return not issubclass(other, collections.Sequence) or NotImplemented

Atomic.register(basestring)

After registration the Atomic class can be used with isinstance and issubclass:

assert isinstance("hello", Atomic) == True

This is still much better than a hard-coded list, because you only need to register the exceptions to the rule, and external users of the code can register their own.

Note that in Python 3 the syntax for specifying metaclasses changed and the basestring abstract superclass was removed, which requires something like the following to be used instead:

class Atomic(metaclass=abc.ABCMeta):
    @classmethod
    def __subclasshook__(cls, other):
        return not issubclass(other, collections.Sequence) or NotImplemented

Atomic.register(str)

If desired, it's possible to write code which is compatible both both Python 2.6+ and 3.x, but doing so requires using a slightly more complicated technique which dynamically creates the needed abstract base class, thereby avoiding syntax errors due to the metaclass syntax difference. This is essentially the same as what Benjamin Peterson's six module's