Is there a way of making strings file-path safe in c#?

Ugh, I hate it when people try to guess at which characters are valid. Besides being completely non-portable (always thinking about Mono), both of the earlier comments missed more 25 invalid characters.

foreach (var c in Path.GetInvalidFileNameChars()) 
{ 
  fileName = fileName.Replace(c, '-'); 
}

Or in VB:

'Clean just a filename
Dim filename As String = "salmnas dlajhdla kjha;dmas'lkasn"
For Each c In IO.Path.GetInvalidFileNameChars
    filename = filename.Replace(c, "")
Next

'See also IO.Path.GetInvalidPathChars

To strip invalid characters:

static readonly char[] invalidFileNameChars = Path.GetInvalidFileNameChars();

// Builds a string out of valid chars
var validFilename = new string(filename.Where(ch => !invalidFileNameChars.Contains(ch)).ToArray());

To replace invalid characters:

static readonly char[] invalidFileNameChars = Path.GetInvalidFileNameChars();

// Builds a string out of valid chars and an _ for invalid ones
var validFilename = new string(filename.Select(ch => invalidFileNameChars.Contains(ch) ? '_' : ch).ToArray());

To replace invalid characters (and avoid potential name conflict like Hell* vs Hell$):

static readonly IList<char> invalidFileNameChars = Path.GetInvalidFileNameChars();

// Builds a string out of valid chars and replaces invalid chars with a unique letter (Moves the Char into the letter range of unicode, starting at "A")
var validFilename = new string(filename.Select(ch => invalidFileNameChars.Contains(ch) ? Convert.ToChar(invalidFileNameChars.IndexOf(ch) + 65) : ch).ToArray());