On the basis that it is easier to ask forgiveness than permission (and, importantly, that the command is safe to run) I would just try to use it and catch the error (OSError in this case - I checked for file does not exist and file is not executable and they both give OSError).
It helps if the executable has something like a --version or --help flag that is a quick no-op.
import subprocess
myexec = "python2.8"
try:
subprocess.call([myexec, '--version']
except OSError:
print "%s not found on path" % myexec
This is not a general solution, but will be the easiest way for a lot of use cases - those where the code needs to look for a single well known executable which is safe to run, or at least safe to run with a given flag.
answered 2012-07-26T08:06:30.777