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I'd like to develop a small/medium-size cross-platform application (including GUI). My background: mostly web applications with MVC architectures, both Python (Pylons + SqlAlchemy) and Java (know the language well, but don't like it that much). I also know some C#. So far, I have no GUI programming experience (neither Windows Forms, Swing nor QT). I plan to use SQLite for data storage: It seems to be a nice cross-platform solution and has some powerful features (e.g. full text search, which SQL Server Compact lacks). I have done some research and these are my favorite options: 1) QT, Python (PyQT or PySide), and SQLAlchemy pros: Python the language open source is strong in the Python world (lots of libraries and users) SQLAlchemy: A fantastic way to interact with a DB and incredibly well documented! cons: compilation, distribution and deployment more difficult? no QT experience QT Designer not as nice as the Visual Studio Winforms designer 2) .NET/Mono, Windows Forms, C#, (Fluent) NHibernate, System.Data.SQLite pros: C# (I like it, especially compared to Java and would like to get more experience in it) The Winforms GUI designer in Visual Studio seems really slick IntelliSense ClickOnce Deployment(?) Windows Forms look and feel good on Windows cons: (Fluent) NHibernate far less documented than SQLAlchemy; also annoying: Fluent docs refer to NHibernate docs which refer to Hibernate (aargh!). But plain NHibernate + XML does not look very comfortable. Windows Forms will not look + behave native on Linux/Mac OS (correct?) fewer open source libraries in the .NET world, fewer OSS users, less documentation in general no WinForms and NHibernate experience </li

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