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So I have a UserControl with some cascading DropDownList s on it. Selecting from list 1 enables list 2, which in turn enables list 3. Once you've made a selection in all three lists, you can move to the next page. The DropDownList s are all inside an UpdatePanel . But the "Next Page" button is outside the UpdatePanel . That button should be disabled until all three lists have a selection, and then it should be enabled again. But since the button is outside the UpdatePanel , it doesn't update when I make selections. ( Edit : The "Next Page" button is on a page that also contains the UserControl .) I know one way to resolve this: var scriptManager = ScriptManager.GetCurrent(this.Page); scriptManager.RegisterPostBackControl(dropDownList1); scriptManager.RegisterPostBackControl(dropDownList2); scriptManager.RegisterPostBackControl(dropDownList3); This ensures a postback when any dropdown list is changed, so that the button can update. But if I do this, I might as simplify by getting rid of the UpdatePanel in the first place. Is there another way, through some clever JavaScript or something, that I can update a control outside an UpdatePanel without having to give up Ajax?

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