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(I'll begin by making it clear, I am not a .NET developer and am not tied to any other environment.)
Recently, I heard that the London Stock Exchange went down for an entire day. I've also heard that the software was written in .NET. Up to this point they would experience performance hits on busy days. People seem to be blaming .NET.
I don't want to debate the story, but it brought to mind the question of just how does .NET scale? How big is too big for .NET?