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I'm trying to create a checksum of a binary file (flv/f4v, etc) to verify the contents of the file between the server and client computers. The application that's running on the client computer is python-based, while the server is using PHP. PHP code is as follows: $fh = fopen($filepath, 'rb'); $contents = fread($fh, filesize($filepath)); $checksum = md5(base64_encode($contents)); fclose($fh); Python code is as follows: def _get_md5(filepath): fh = open(filepath, 'rb') md5 = hashlib.md5() md5.update(f.read().encode('base64')) checksum = md5.hexdigest() f.close() return checksum on the particular file I'm testing, the PHP and Python md5 hash strings are as follows, respectively: cfad0d835eb88e5342e843402cc42764 0a96e9cc3bb0354d783dfcb729248ce0 Server is running CentOS, while the client is a MacOSX environment. I would greatly appreciate any help in understanding why the two are generating different hash results, or if it something I overlooked (I am relatively new to Python...). Thank you! [post mortem: the problem was ultimately the difference between Python and PHP's base64 encoding varieties. MD5 works the same between the two scripting platforms (at least using .hexdigest() in Python).]

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