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I do know that PDO does not support multiple queries getting executed in one statement. I've been Googleing and found few posts talking about PDO_MYSQL and PDO_MYSQLND.
PDO_MySQL is a more dangerous application than any other traditional MySQL applications. Traditional MySQL allows only a single SQL query. In PDO_MySQL there is no such limitation, but you risk to be injected with multiple queries.
From: Protection against SQL Injection using PDO and Zend Framework (June 2010; by Julian)
It seems like PDO_MYSQL and PDO_MYSQLND do provide support for multiple queries, but I am not able to find more information about them. Were these projects discontinued? Is there any way now to run multiple queries using PDO.