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Python 2 has two integer types: int, which is a signed integer whose size equals your machine's word size (but is always at least 32 bits), and long, which is unlimited in size.
Python 3 has only one integer type, which is called int but is equivalent to a Python 2 long.
You have a couple of options using gmpy. Here is one example using gmpy:
>>> from gmpy import mpz
>>> a=mpz(7)
>>> bin(a)
'0b111'
>>> a=a.setbit(48)
>>> bin(a)
'0b1000000000000000000000000000000000000000000000111'
>>>
gmpy2 is the development version of gmpy and includes a new type called xmpz that allows more direct access to the bits.
>>> from gmpy2 import xmpz
>>> a=xmpz(7)
>>> bin(a)
'0b111'
>>> a[48]=1
>>> bin(a)
'0b1000000000000000000000000000000000000000000000111'
>>>
There are other solutions such as bitarray you might want to look at.
Disclaimer: I maintain gmpy and gmpy2.