How to modify hotkey binding for mathematica system menu items?

This problem has bothered me for a long time.As we know,in mathematica we can modify hotkey bindings through two files "KeyEventTranslations.tr" and "MenuSetup.tr",but some hotkeys that by default bind to system menu items(for example, in windows: Alt+F bind to File menu,Alt+E bind to Edit menu,Alt+I bind to Insert menu,etc.) don't show up in these files. My question is how to customize these kind of hotkeys? So that I can assign actions I have used more frequently to them.

I have noticed that in the file "MenuSetup.tr",changing position of the '&' symbol doesn't affect hotkey binding (for example,changing Menu["&File",{...}] to Menu["Fi&le",{...}]).

Any suggestions? Thank you very much!