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I am sorry that I can't reproduce the error with a simpler example, and my code is too complicated to post. If I run the program in IPython shell instead of the regular Python, things work out well. I looked up some previous notes on this problem. They were all caused by using pool to call function defined within a class function. But this is not the case for me. Exception in thread Thread-3: Traceback (most recent call last): File "/usr/lib64/python2.7/threading.py", line 552, in __bootstrap_inner self.run() File "/usr/lib64/python2.7/threading.py", line 505, in run self.__target(*self.__args, **self.__kwargs) File "/usr/lib64/python2.7/multiprocessing/pool.py", line 313, in _handle_tasks put(task) PicklingError: Can't pickle <type 'function'>: attribute lookup __builtin__.function failed I would appreciate any help. Update : The function I pickle is defined at the top level of the module. Though it calls a function that contains a nested function. i.e, f() calls g() calls h() which has a nested function i() , and I am calling pool.apply_async(f) . f() , g() , h() are all defined at the top level. I tried simpler example with this pattern and it works though.

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