How do you reverse a string in-place?

Seems like I'm 3 years late to the party...

Unfortunately you can't as has been pointed out. See Are JavaScript strings immutable? Do I need a "string builder" in JavaScript?

The next best thing you can do is to create a "view" or "wrapper", which takes a string and reimplements whatever parts of the string API you are using, but pretending the string is reversed. For example:

var identity = function(x){return x};

function LazyString(s) {
    this.original = s;

    this.length = s.length;
    this.start = 0; this.stop = this.length; this.dir = 1; // "virtual" slicing
    // (dir=-1 if reversed)

    this._caseTransform = identity;
}

// syntactic sugar to create new object:
function S(s) {
    return new LazyString(s);
}

//We now implement a `"...".reversed` which toggles a flag which will change our math:

(function(){ // begin anonymous scope
    var x = LazyString.prototype;

    // Addition to the String API
    x.reversed = function() {
        var s = new LazyString(this.original);

        s.start = this.stop - this.dir;
        s.stop = this.start - this.dir;
        s.dir = -1*this.dir;
        s.length = this.length;

        s._caseTransform = this._caseTransform;
        return s;
    }

//We also override string coercion for some extra versatility (not really necessary):

    // OVERRIDE STRING COERCION
    //   - for string concatenation e.g. "abc"+reversed("abc")
    x.toString = function() {
        if (typeof this._realized == 'undefined') {  // cached, to avoid recalculation
            this._realized = this.dir==1 ?
                this.original.slice(this.start,this.stop) : 
                this.original.slice(this.stop+1,this.start+1).split("").reverse().join("");

            this._realized = this._caseTransform.call(this._realized, this._realized);
        }
        return thi