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Instead of using an in-memory database, you could use a regular (persisted) database. You can still use in-memory tables even then (create memory table).
The easiest way to persist a completely in-memory database to disk is to use the SCRIPT TO 'fileName' SQL statement. This will create an SQL script. The data is stored in text form, which doesn't sound like the most efficient solution. However usually the bottleneck is the disk anyway and not formatting / parsing the text.
Another option is to create another database, link the tables with the in-memory database (using create linked table or the link_schema function), and then use create table as select to persist the tables.